This Action’s activities will be organized in four Working Groups:
Genetic Association Studies (WG1)
Functional Genomics (WG2)
Next Generation Sequencing (WG3)
Statistical Modeling (WG4)
WG1 will comprise all activities related to the identification of new CRC genetic susceptibility variants and correlation of known and newly identified CRC genetic susceptibility variants with CRC survival and treatment response, as well as with CRC subtypes.
WG2 will cover research undertaken by participants regarding fine mapping and functional studies for known and newly identified CRC genetic susceptibility variants.
WG3 will include all activities related to the identification of new predisposition CRC genes by next generation sequencing.
Finally, WG4 will consist of research tasks involved in statistical analyses of gene-gene (epistasis and hereditary CRC modifiers) and gene-environment interactions for CRC genetic susceptibility variants, with a final objective of developing a high-risk profile for CRC to be used as a molecular tool for personalized CRC medicine.